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Spatially-resolved subtype progression reveals metabolic vulnerabilities in pancreatic ductal adenocarcinoma | Molecular Cancer | Springer Nature Link

The disadvantage of this approach is that MSBT shows limited solubility in water and that cyanoacetate-based probes are unstable under MS conditions, making the analysis very complicated (Aroca et al., 2017

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A., Zou H., Tao J., Chen Q., Wan Y., The Emerging Role of Deubiquitinating Enzymes in Genomic Integrity, Diseases, and Therapeutics, Cell Biosci., 2016, 6 (1), 62